In Europe, combating cancer’s early roots, often initiated during adolescence, is a pressing challenge. The EU-funded SUNRISE project aims to tackle this by introducing a digitally enhanced life-skills programme. Tailored to diverse socio-economic, cultural, and environmental backgrounds, SUNRISE integrates evidence-based smoking prevention tools with innovative approaches like peer social media campaigns, advertising literacy training, educational games, social robots and conversational assistants. Developed through schools-as-living-labs collaboration with educators, adolescents, parents, and experts, the programme will be implemented across 154 schools and 7 500 students in eight countries. SUNRISE strives to redefine cancer prevention for adolescents through effective strategies and sustainable solutions.